Drug interactions
Ivacaftor + Netupitant-palonosetron
Severity: Moderate
Ivacaftor and Netupitant-palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant may increase ivacaftor exposure, which could increase adverse effects such as headache, transaminase elevation and dizziness.
What this interaction means in plain words
Ivacaftor and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivacaftor belongs to Miscellaneous; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
Netupitant inhibits CYP3A4, reducing ivacaftor metabolism.
What to do
Reduce the ivacaftor dose per product labeling for moderate CYP3A inhibitors. Monitor liver enzymes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Netupitant-palonosetron?
MediHelp rates the interaction as moderate. Ivacaftor and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant may increase ivacaftor exposure, which could increase adverse effects such as headache, transaminase elevation and dizziness.
How serious is the interaction between Ivacaftor and Netupitant-palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ivacaftor dose per product labeling for moderate CYP3A inhibitors. Monitor liver enzymes.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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