Drug interactions
Ivacaftor + Nilotinib
Severity: Moderate
Ivacaftor and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor inhibits P-glycoprotein and weakly CYP3A4, which may modestly raise nilotinib exposure. Higher nilotinib levels raise concern for QT prolongation.
What this interaction means in plain words
Ivacaftor and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivacaftor belongs to Miscellaneous; Nilotinib belongs to Oncology.
Why it happens
Ivacaftor inhibits P-glycoprotein efflux and weakly inhibits CYP3A4.
What to do
Monitor the QTc and electrolytes, and watch for nilotinib adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Nilotinib?
MediHelp rates the interaction as moderate. Ivacaftor and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivacaftor inhibits P-glycoprotein and weakly CYP3A4, which may modestly raise nilotinib exposure. Higher nilotinib levels raise concern for QT prolongation.
How serious is the interaction between Ivacaftor and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the QTc and electrolytes, and watch for nilotinib adverse effects.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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