Drug interactions
Ivacaftor + Oxybutynin
Severity: Minor
Ivacaftor and Oxybutynin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor is a CYP3A substrate, and oxybutynin is not an established CYP3A4 inhibitor, so a clinically meaningful rise in ivacaftor exposure is not expected. The legacy mechanism appears unsupported by known pharmacology.
What this interaction means in plain words
Ivacaftor and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivacaftor belongs to Miscellaneous; Oxybutynin belongs to Genitourinary.
Why it happens
No established mechanism; oxybutynin is a CYP3A4 substrate and not a recognised inhibitor.
What to do
No dose adjustment is required; monitor for ivacaftor adverse effects such as headache or liver enzyme elevation as part of routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxybutynin
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Oxybutynin?
MediHelp rates the interaction as minor. Ivacaftor and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor is a CYP3A substrate, and oxybutynin is not an established CYP3A4 inhibitor, so a clinically meaningful rise in ivacaftor exposure is not expected. The legacy mechanism appears unsupported by known pharmacology.
How serious is the interaction between Ivacaftor and Oxybutynin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for ivacaftor adverse effects such as headache or liver enzyme elevation as part of routine care.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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