Drug interactions
Ivacaftor + Topotecan
Severity: Moderate
Ivacaftor and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its M1 metabolite weakly inhibit P-glycoprotein and may increase exposure to topotecan. This could intensify bone marrow suppression and gastrointestinal effects, especially with oral topotecan.
What this interaction means in plain words
Ivacaftor and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivacaftor belongs to Miscellaneous; Topotecan belongs to Oncology.
Why it happens
Ivacaftor inhibits P-glycoprotein-mediated efflux of topotecan.
What to do
Monitor blood counts regularly and reduce the topotecan dose if excessive myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporin + Topotecan Major
- Darunavir + Topotecan Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Topotecan?
MediHelp rates the interaction as moderate. Ivacaftor and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivacaftor and its M1 metabolite weakly inhibit P-glycoprotein and may increase exposure to topotecan. This could intensify bone marrow suppression and gastrointestinal effects, especially with oral topotecan.
How serious is the interaction between Ivacaftor and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly and reduce the topotecan dose if excessive myelosuppression occurs.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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