Drug interactions
Ivacaftor + Vincristine
Severity: Moderate
Ivacaftor and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its M1 metabolite can inhibit P-glycoprotein, which helps clear vincristine from tissues. Higher vincristine exposure could worsen neurotoxicity, constipation and myelosuppression.
What this interaction means in plain words
Ivacaftor and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivacaftor belongs to Miscellaneous; Vincristine belongs to Oncology.
Why it happens
Ivacaftor weakly inhibits P-gp efflux, potentially raising systemic vincristine exposure.
What to do
Monitor for peripheral neuropathy, constipation or ileus and blood counts during coadministration. Consider reducing the vincristine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Vincristine?
MediHelp rates the interaction as moderate. Ivacaftor and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivacaftor and its M1 metabolite can inhibit P-glycoprotein, which helps clear vincristine from tissues. Higher vincristine exposure could worsen neurotoxicity, constipation and myelosuppression.
How serious is the interaction between Ivacaftor and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy, constipation or ileus and blood counts during coadministration. Consider reducing the vincristine dose if toxicity appears.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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