Drug interactions
Ivermectin + Rifampin
Severity: Moderate
Ivermectin and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent inducer of CYP3A4 and P-glycoprotein and may lower ivermectin concentrations. This could reduce efficacy in treating parasitic infections, though clinical data are limited.
What this interaction means in plain words
Ivermectin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP3A4 and P-glycoprotein, increasing ivermectin clearance and reducing its bioavailability.
What to do
Monitor for clinical or parasitological response and consider repeat or extended dosing if treatment fails. Consider timing ivermectin when possible to avoid sustained rifampin induction only if alternatives exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
- Ivermectin + Warfarin Moderate
Frequently asked questions
Can I take Ivermectin with Rifampin?
MediHelp rates the interaction as moderate. Ivermectin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a potent inducer of CYP3A4 and P-glycoprotein and may lower ivermectin concentrations. This could reduce efficacy in treating parasitic infections, though clinical data are limited.
How serious is the interaction between Ivermectin and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clinical or parasitological response and consider repeat or extended dosing if treatment fails. Consider timing ivermectin when possible to avoid sustained rifampin induction only if alternatives exist.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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