Drug interactions
Ivermectin + Tepotinib
Severity: Moderate
Ivermectin and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may raise ivermectin concentrations. The clinical effect is probably small but could increase CNS or other adverse effects.
What this interaction means in plain words
Ivermectin and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivermectin belongs to Anti Parasitic; Tepotinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux increases ivermectin exposure.
What to do
Use standard ivermectin doses and monitor for dizziness, confusion and gastrointestinal effects. Separate dosing times if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Warfarin Moderate
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Ivermectin with Tepotinib?
MediHelp rates the interaction as moderate. Ivermectin and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein and may raise ivermectin concentrations. The clinical effect is probably small but could increase CNS or other adverse effects.
How serious is the interaction between Ivermectin and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use standard ivermectin doses and monitor for dizziness, confusion and gastrointestinal effects. Separate dosing times if feasible.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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