Drug interactions
Ivermectin + Lasmiditan
Severity: Moderate
Ivermectin and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits intestinal P-glycoprotein, which may increase ivermectin exposure. Clinical significance is uncertain given ivermectin's wide safety margin, but additive CNS effects such as dizziness are possible.
What this interaction means in plain words
Ivermectin and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivermectin belongs to Anti Parasitic; Lasmiditan belongs to Central Nervous System.
Why it happens
Inhibition of intestinal P-glycoprotein reduces efflux of ivermectin.
What to do
Monitor for dizziness, sedation and other CNS effects if used together. Consider separating dosing in time and avoid repeated ivermectin dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
- Ivermectin + Warfarin Moderate
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Ivermectin with Lasmiditan?
MediHelp rates the interaction as moderate. Ivermectin and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits intestinal P-glycoprotein, which may increase ivermectin exposure. Clinical significance is uncertain given ivermectin's wide safety margin, but additive CNS effects such as dizziness are possible.
How serious is the interaction between Ivermectin and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, sedation and other CNS effects if used together. Consider separating dosing in time and avoid repeated ivermectin dosing.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Quinidine, Rifampin. The full list is on the Ivermectin page.
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