Drug interactions
Ivermectin + Sotorasib
Severity: Moderate
Ivermectin and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-glycoprotein inhibitor and is expected to raise concentrations of P-gp substrates such as ivermectin. Reduced efficacy is unlikely, but increased exposure and adverse effects are possible.
What this interaction means in plain words
Ivermectin and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivermectin belongs to Anti Parasitic; Sotorasib belongs to Oncology.
Why it happens
Sotorasib inhibits P-glycoprotein efflux, increasing ivermectin exposure.
What to do
Monitor for neurologic and gastrointestinal adverse effects of ivermectin during co-use. Avoid unnecessary repeat or high-dose ivermectin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Tepotinib Moderate
- Ivermectin + Warfarin Moderate
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Ivermectin with Sotorasib?
MediHelp rates the interaction as moderate. Ivermectin and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-glycoprotein inhibitor and is expected to raise concentrations of P-gp substrates such as ivermectin. Reduced efficacy is unlikely, but increased exposure and adverse effects are possible.
How serious is the interaction between Ivermectin and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurologic and gastrointestinal adverse effects of ivermectin during co-use. Avoid unnecessary repeat or high-dose ivermectin.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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