Drug interactions
Ivermectin + Quinidine
Severity: Moderate
Ivermectin and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-glycoprotein and may raise ivermectin concentrations, including in the central nervous system. This could increase neurotoxicity, though clinical data are limited.
What this interaction means in plain words
Ivermectin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivermectin belongs to Anti Parasitic; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits P-glycoprotein efflux of ivermectin, increasing tissue and CNS exposure.
What to do
Monitor for neurologic effects such as dizziness, ataxia or confusion. Quinidine also prolongs QT, so avoid unnecessary co-use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
- Ivermectin + Warfarin Moderate
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Ivermectin with Quinidine?
MediHelp rates the interaction as moderate. Ivermectin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits P-glycoprotein and may raise ivermectin concentrations, including in the central nervous system. This could increase neurotoxicity, though clinical data are limited.
How serious is the interaction between Ivermectin and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurologic effects such as dizziness, ataxia or confusion. Quinidine also prolongs QT, so avoid unnecessary co-use.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Rifampin. The full list is on the Ivermectin page.
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