Drug interactions
Ivosidenib + Losartan
Severity: Moderate
Ivosidenib and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may affect CYP2C9, which could change formation of losartan's active metabolite and lower or alter its antihypertensive effect. The effect is generally modest and manageable.
What this interaction means in plain words
Ivosidenib and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Losartan belongs to Cardiovascular.
Why it happens
Ivosidenib induces CYP3A4 and possibly CYP2C9, altering losartan clearance and active metabolite formation.
What to do
Monitor blood pressure and increase the losartan dose if control is lost, or switch to another antihypertensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Losartan?
MediHelp rates the interaction as moderate. Ivosidenib and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may affect CYP2C9, which could change formation of losartan's active metabolite and lower or alter its antihypertensive effect. The effect is generally modest and manageable.
How serious is the interaction between Ivosidenib and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and increase the losartan dose if control is lost, or switch to another antihypertensive.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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