Drug interactions
Ivosidenib + Lurasidone
Severity: Major
Ivosidenib and Lurasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib is a CYP3A4 inducer and can lower lurasidone concentrations, potentially reducing its antipsychotic efficacy and risking relapse. Lurasidone labeling advises against use with strong CYP3A4 inducers, and ivosidenib's induction is moderate.
What this interaction means in plain words
Ivosidenib and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivosidenib belongs to Oncology; Lurasidone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by ivosidenib, increasing lurasidone metabolism.
What to do
Avoid the combination if possible. If it is unavoidable, monitor for loss of psychiatric control and consider a lurasidone dose increase guided by clinical response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Lurasidone?
MediHelp rates the interaction as major. Ivosidenib and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib is a CYP3A4 inducer and can lower lurasidone concentrations, potentially reducing its antipsychotic efficacy and risking relapse. Lurasidone labeling advises against use with strong CYP3A4 inducers, and ivosidenib's induction is moderate.
How serious is the interaction between Ivosidenib and Lurasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is unavoidable, monitor for loss of psychiatric control and consider a lurasidone dose increase guided by clinical response.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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