Drug interactions
Ivosidenib + Mefloquine
Severity: Major
Ivosidenib and Mefloquine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib prolongs the QT interval and mefloquine may add to this effect, increasing the risk of torsades de pointes. Ivosidenib also induces CYP3A4, which may reduce mefloquine concentrations and efficacy.
What this interaction means in plain words
Ivosidenib and Mefloquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivosidenib belongs to Oncology; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, plus CYP3A4 induction by ivosidenib lowering mefloquine exposure.
What to do
Avoid the combination and use an alternative antimalarial. If unavoidable, monitor the ECG and electrolytes and be alert to reduced antimalarial efficacy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Mefloquine?
MediHelp rates the interaction as major. Ivosidenib and Mefloquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib prolongs the QT interval and mefloquine may add to this effect, increasing the risk of torsades de pointes. Ivosidenib also induces CYP3A4, which may reduce mefloquine concentrations and efficacy.
How serious is the interaction between Ivosidenib and Mefloquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antimalarial. If unavoidable, monitor the ECG and electrolytes and be alert to reduced antimalarial efficacy.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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