Drug interactions
Ivosidenib + Paliperidone
Severity: Major
Ivosidenib and Paliperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can prolong the QTc interval, and paliperidone has similar effects. Using both may increase the chance of torsades de pointes, particularly with electrolyte disturbances.
What this interaction means in plain words
Ivosidenib and Paliperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivosidenib belongs to Oncology; Paliperidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination or substitute an alternative antipsychotic with lower QT liability. If unavoidable, monitor ECG and electrolytes regularly and reduce or hold ivosidenib per labeling if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Paliperidone?
MediHelp rates the interaction as major. Ivosidenib and Paliperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib can prolong the QTc interval, and paliperidone has similar effects. Using both may increase the chance of torsades de pointes, particularly with electrolyte disturbances.
How serious is the interaction between Ivosidenib and Paliperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination or substitute an alternative antipsychotic with lower QT liability. If unavoidable, monitor ECG and electrolytes regularly and reduce or hold ivosidenib per labeling if QTc becomes markedly prolonged.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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