Drug interactions
Ivosidenib + Perphenazine
Severity: Major
Ivosidenib and Perphenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib prolongs the QT interval, and perphenazine has similar liability, so combined use raises the risk of torsades de pointes. Risk is greater with electrolyte disturbance or underlying heart disease.
What this interaction means in plain words
Ivosidenib and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivosidenib belongs to Oncology; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Avoid the combination where an alternative antipsychotic is possible. If both are needed, monitor ECG and keep potassium and magnesium in the normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Perphenazine?
MediHelp rates the interaction as major. Ivosidenib and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib prolongs the QT interval, and perphenazine has similar liability, so combined use raises the risk of torsades de pointes. Risk is greater with electrolyte disturbance or underlying heart disease.
How serious is the interaction between Ivosidenib and Perphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antipsychotic is possible. If both are needed, monitor ECG and keep potassium and magnesium in the normal range.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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