Drug interactions
Ivosidenib + Rimegepant
Severity: Moderate
Ivosidenib and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and can lower rimegepant concentrations. This may reduce migraine efficacy, and labeling advises against use with moderate CYP3A inducers.
What this interaction means in plain words
Ivosidenib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Rimegepant belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 metabolism, increasing rimegepant clearance.
What to do
Avoid the combination where possible and use another acute migraine therapy if rimegepant efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Rimegepant?
MediHelp rates the interaction as moderate. Ivosidenib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and can lower rimegepant concentrations. This may reduce migraine efficacy, and labeling advises against use with moderate CYP3A inducers.
How serious is the interaction between Ivosidenib and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use another acute migraine therapy if rimegepant efficacy is lost.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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