Drug interactions
Ivosidenib + Solifenacin
Severity: Major
Ivosidenib and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib prolongs the QT interval, and solifenacin may add to this. Ivosidenib is also a CYP3A4 inducer, which could lower solifenacin exposure and reduce its efficacy.
What this interaction means in plain words
Ivosidenib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivosidenib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation, plus induction of CYP3A4 by ivosidenib that lowers solifenacin levels.
What to do
Avoid the combination if possible. If both are used, monitor ECG and electrolytes and assess whether solifenacin is still effective.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Solifenacin?
MediHelp rates the interaction as major. Ivosidenib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib prolongs the QT interval, and solifenacin may add to this. Ivosidenib is also a CYP3A4 inducer, which could lower solifenacin exposure and reduce its efficacy.
How serious is the interaction between Ivosidenib and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If both are used, monitor ECG and electrolytes and assess whether solifenacin is still effective.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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