Drug interactions
Ivosidenib + Torsemide
Severity: Moderate
Ivosidenib and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Torsemide is mainly cleared by CYP2C9. Ivosidenib is an inducer of CYP enzymes, including CYP2C9, and may lower torsemide exposure, reducing diuretic effect.
What this interaction means in plain words
Ivosidenib and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Torsemide belongs to Cardiovascular.
Why it happens
Ivosidenib induces CYP2C9, increasing torsemide metabolism.
What to do
Monitor weight, edema and blood pressure and increase the torsemide dose if diuretic response falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Torsemide?
MediHelp rates the interaction as moderate. Ivosidenib and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Torsemide is mainly cleared by CYP2C9. Ivosidenib is an inducer of CYP enzymes, including CYP2C9, and may lower torsemide exposure, reducing diuretic effect.
How serious is the interaction between Ivosidenib and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema and blood pressure and increase the torsemide dose if diuretic response falls.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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