Drug interactions
Ixazomib + Nafcillin
Severity: Moderate
Ixazomib and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower ixazomib levels. The clinical impact is uncertain but reduced efficacy is possible with prolonged courses.
What this interaction means in plain words
Ixazomib and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4 (likely via PXR activation), increasing ixazomib clearance.
What to do
Use a non-inducing antibiotic where feasible, such as an alternative beta-lactam. If nafcillin is required, monitor myeloma response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Frequently asked questions
Can I take Ixazomib with Nafcillin?
MediHelp rates the interaction as moderate. Ixazomib and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and may lower ixazomib levels. The clinical impact is uncertain but reduced efficacy is possible with prolonged courses.
How serious is the interaction between Ixazomib and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing antibiotic where feasible, such as an alternative beta-lactam. If nafcillin is required, monitor myeloma response.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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