Drug interactions
Ixekizumab + Measles mumps and rubella vaccine
Severity: Major
Ixekizumab and Measles mumps and rubella vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live vaccines should be avoided during ixekizumab therapy because of uncertain vaccine response and safety. Ixekizumab selectively blocks IL-17A, so the risk of disseminated vaccine virus is likely low but not established.
What this interaction means in plain words
Ixekizumab and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ixekizumab belongs to Miscellaneous; Measles mumps and rubella vaccine belongs to Miscellaneous.
Why it happens
Immune modulation by ixekizumab may impair vaccine response and live vaccine safety.
What to do
Complete live vaccinations before starting ixekizumab, ideally at least 4 weeks prior. Avoid live vaccines during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Ixekizumab
- Ixekizumab + Upadacitinib Major
- Ifosfamide + Ixekizumab Moderate
- Ixekizumab + Lomustine Moderate
- Carbamazepine + Ixekizumab Minor
- Cyclosporin + Ixekizumab Minor
- Ethosuximide + Ixekizumab Minor
Frequently asked questions
Can I take Ixekizumab with Measles mumps and rubella vaccine?
MediHelp rates the interaction as major. Ixekizumab and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Live vaccines should be avoided during ixekizumab therapy because of uncertain vaccine response and safety. Ixekizumab selectively blocks IL-17A, so the risk of disseminated vaccine virus is likely low but not established.
How serious is the interaction between Ixekizumab and Measles mumps and rubella vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete live vaccinations before starting ixekizumab, ideally at least 4 weeks prior. Avoid live vaccines during treatment.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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