Drug interactions
Ixekizumab + Upadacitinib
Severity: Major
Ixekizumab and Upadacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress immune pathways, and combined use may raise the risk of serious infection. Combination therapy has not been studied and is not recommended.
What this interaction means in plain words
Ixekizumab and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ixekizumab belongs to Miscellaneous; Upadacitinib belongs to Musculoskeletal.
Why it happens
Additive immunosuppression through JAK inhibition and IL-17A blockade.
What to do
Avoid combined use. If both are considered, monitor closely for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Other interactions of Ixekizumab
- Ixekizumab + Measles mumps and rubella vaccine Major
- Ifosfamide + Ixekizumab Moderate
- Ixekizumab + Lomustine Moderate
- Carbamazepine + Ixekizumab Minor
- Cyclosporin + Ixekizumab Minor
- Ethosuximide + Ixekizumab Minor
Frequently asked questions
Can I take Ixekizumab with Upadacitinib?
MediHelp rates the interaction as major. Ixekizumab and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress immune pathways, and combined use may raise the risk of serious infection. Combination therapy has not been studied and is not recommended.
How serious is the interaction between Ixekizumab and Upadacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use. If both are considered, monitor closely for infection.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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