Drug interactions
Ixekizumab + Phenytoin
Severity: Minor
Ixekizumab and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic inflammation suppresses CYP450 expression, and ixekizumab may reverse this as inflammation is controlled. Clearance of CYP substrates with a narrow therapeutic index such as phenytoin could therefore change when ixekizumab is started or stopped. The clinical effect is expected to be small.
What this interaction means in plain words
Ixekizumab and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixekizumab belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
Why it happens
Normalisation of cytokine-suppressed CYP450 enzyme expression after IL-17A blockade may alter phenytoin metabolism.
What to do
Check phenytoin concentrations and clinical response when starting or stopping ixekizumab, and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Ixekizumab
- Ixekizumab + Measles mumps and rubella vaccine Major
- Ixekizumab + Upadacitinib Major
- Ifosfamide + Ixekizumab Moderate
- Ixekizumab + Lomustine Moderate
- Carbamazepine + Ixekizumab Minor
- Cyclosporin + Ixekizumab Minor
Frequently asked questions
Can I take Ixekizumab with Phenytoin?
MediHelp rates the interaction as minor. Ixekizumab and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation suppresses CYP450 expression, and ixekizumab may reverse this as inflammation is controlled. Clearance of CYP substrates with a narrow therapeutic index such as phenytoin could therefore change when ixekizumab is started or stopped. The clinical effect is expected to be small.
How serious is the interaction between Ixekizumab and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check phenytoin concentrations and clinical response when starting or stopping ixekizumab, and adjust the dose if needed.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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