Drug interactions
Ixekizumab + Theophylline
Severity: Minor
Ixekizumab and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic inflammation suppresses CYP450 enzymes, and an IL-17A inhibitor that reduces inflammation may restore enzyme activity. Theophylline levels could therefore fall. A meaningful effect has not been demonstrated.
What this interaction means in plain words
Ixekizumab and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixekizumab belongs to Miscellaneous; Theophylline belongs to Respiratory.
Why it happens
Normalization of cytokine-suppressed CYP450 (including CYP1A2) expression as inflammation resolves.
What to do
Consider checking theophylline concentrations after starting or stopping ixekizumab, especially if control of the underlying disease changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ixekizumab and Theophylline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Ixekizumab
- Ixekizumab + Measles mumps and rubella vaccine Major
- Ixekizumab + Upadacitinib Major
- Ifosfamide + Ixekizumab Moderate
- Ixekizumab + Lomustine Moderate
- Carbamazepine + Ixekizumab Minor
- Cyclosporin + Ixekizumab Minor
Frequently asked questions
Can I take Ixekizumab with Theophylline?
MediHelp rates the interaction as minor. Ixekizumab and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation suppresses CYP450 enzymes, and an IL-17A inhibitor that reduces inflammation may restore enzyme activity. Theophylline levels could therefore fall. A meaningful effect has not been demonstrated.
How serious is the interaction between Ixekizumab and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider checking theophylline concentrations after starting or stopping ixekizumab, especially if control of the underlying disease changes.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
