Drug interactions
Japanese encephalitis virus vaccine + Ocrelizumab
Severity: Moderate
Japanese encephalitis virus vaccine and Ocrelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ocrelizumab-induced B-cell depletion may blunt the antibody response to the inactivated Japanese encephalitis vaccine, so travelers may be inadequately protected.
What this interaction means in plain words
Japanese encephalitis virus vaccine and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Depletion of CD20-positive B cells impairs humoral immune responses to vaccine antigens.
What to do
Vaccinate at least 2 weeks before starting ocrelizumab if possible. If given during treatment, consider serologic confirmation of response and add mosquito-avoidance measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Japanese encephalitis virus vaccine with Ocrelizumab?
MediHelp rates the interaction as moderate. Japanese encephalitis virus vaccine and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ocrelizumab-induced B-cell depletion may blunt the antibody response to the inactivated Japanese encephalitis vaccine, so travelers may be inadequately protected.
How serious is the interaction between Japanese encephalitis virus vaccine and Ocrelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before starting ocrelizumab if possible. If given during treatment, consider serologic confirmation of response and add mosquito-avoidance measures.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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