Drug interactions
Japanese encephalitis virus vaccine + Temsirolimus
Severity: Moderate
Japanese encephalitis virus vaccine and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus may reduce the response to inactivated Japanese encephalitis vaccine. Travelers may therefore be less protected than expected.
What this interaction means in plain words
Japanese encephalitis virus vaccine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition impairs T- and B-cell responses to vaccine antigens.
What to do
Vaccinate before temsirolimus if possible, and reassess the need for travel to endemic areas. Reinforce mosquito-avoidance measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Japanese encephalitis virus vaccine with Temsirolimus?
MediHelp rates the interaction as moderate. Japanese encephalitis virus vaccine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus may reduce the response to inactivated Japanese encephalitis vaccine. Travelers may therefore be less protected than expected.
How serious is the interaction between Japanese encephalitis virus vaccine and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before temsirolimus if possible, and reassess the need for travel to endemic areas. Reinforce mosquito-avoidance measures.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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