Drug interactions
Ketamine + Mirtazapine
Severity: Moderate
Ketamine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so together they may deepen sedation and impair psychomotor function. The effect matters most with anesthetic or procedural ketamine doses or when other sedatives are on board.
What this interaction means in plain words
Ketamine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depression via NMDA antagonism from ketamine and H1 antagonism from mirtazapine.
What to do
Monitor level of consciousness and respiratory status during ketamine administration. Advise patients not to drive or operate machinery after ketamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Mirtazapine?
MediHelp rates the interaction as moderate. Ketamine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so together they may deepen sedation and impair psychomotor function. The effect matters most with anesthetic or procedural ketamine doses or when other sedatives are on board.
How serious is the interaction between Ketamine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of consciousness and respiratory status during ketamine administration. Advise patients not to drive or operate machinery after ketamine.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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