Drug interactions
Ketamine + Stiripentol
Severity: Moderate
Ketamine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces several CYP enzymes, including CYP3A4 and CYP2B6 involved in ketamine metabolism. Ketamine exposure may therefore be altered unpredictably, with possible increases in sedation or reduced effect. Stiripentol also has its own sedative properties.
What this interaction means in plain words
Ketamine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed inhibition and induction of CYP2B6 and CYP3A4 by stiripentol alters ketamine clearance, with additive sedation.
What to do
Titrate ketamine to clinical effect and monitor sedation, hemodynamics and recovery time. Adjust the dose according to observed response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Stiripentol
Frequently asked questions
Can I take Ketamine with Stiripentol?
MediHelp rates the interaction as moderate. Ketamine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces several CYP enzymes, including CYP3A4 and CYP2B6 involved in ketamine metabolism. Ketamine exposure may therefore be altered unpredictably, with possible increases in sedation or reduced effect. Stiripentol also has its own sedative properties.
How serious is the interaction between Ketamine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to clinical effect and monitor sedation, hemodynamics and recovery time. Adjust the dose according to observed response.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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