Drug interactions
Ketamine + Trazodone
Severity: Moderate
Ketamine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so combination can deepen sedation and impair psychomotor function. Ketamine may also change blood pressure and heart rate, complicating hemodynamic effects of trazodone.
What this interaction means in plain words
Ketamine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor level of sedation and hemodynamics, and reduce doses if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Trazodone?
MediHelp rates the interaction as moderate. Ketamine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so combination can deepen sedation and impair psychomotor function. Ketamine may also change blood pressure and heart rate, complicating hemodynamic effects of trazodone.
How serious is the interaction between Ketamine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of sedation and hemodynamics, and reduce doses if excessive sedation occurs.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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