Drug interactions
Ketamine + Trimipramine
Severity: Moderate
Ketamine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on the central nervous system and can produce additive sedation. Tricyclics may also exaggerate the sympathomimetic cardiovascular effects of ketamine such as hypertension and tachycardia.
What this interaction means in plain words
Ketamine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression and potentiation of ketamine's sympathomimetic effects through inhibition of catecholamine reuptake.
What to do
Monitor sedation, blood pressure and heart rate during ketamine administration. Use lower ketamine doses where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Trimipramine?
MediHelp rates the interaction as moderate. Ketamine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on the central nervous system and can produce additive sedation. Tricyclics may also exaggerate the sympathomimetic cardiovascular effects of ketamine such as hypertension and tachycardia.
How serious is the interaction between Ketamine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and heart rate during ketamine administration. Use lower ketamine doses where appropriate.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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