Drug interactions
ketoconazole + lomitapide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Marked ↑ lomitapide; contraindicated.
Mechanism of action
Strong CYP3A4 inhibition.
Clinical management
Contraindicated.
Drug reference
References
Frequently asked questions
Can I take ketoconazole with lomitapide?
The interaction is rated: Contraindicated. Marked ↑ lomitapide; contraindicated.
How serious is the interaction between ketoconazole and lomitapide?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between ketoconazole and lomitapide managed?
Contraindicated.
Why do ketoconazole and lomitapide interact?
Strong CYP3A4 inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.