Drug interactions
Ketoconazole + Macimorelin
Severity: Major
Ketoconazole and Macimorelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may raise macimorelin levels, and macimorelin can prolong QT. Ketoconazole also has QT effects.
What this interaction means in plain words
Ketoconazole and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoconazole belongs to Anti Fungals; Macimorelin belongs to Endocrine.
Why it happens
CYP3A4 inhibition reduces macimorelin metabolism, with additive QT effects.
What to do
Avoid concurrent use around the test, or delay testing until the strong CYP3A inhibitor is cleared. Check ECG if the test is essential.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Ketoconazole with Macimorelin?
MediHelp rates the interaction as major. Ketoconazole and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole may raise macimorelin levels, and macimorelin can prolong QT. Ketoconazole also has QT effects.
How serious is the interaction between Ketoconazole and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use around the test, or delay testing until the strong CYP3A inhibitor is cleared. Check ECG if the test is essential.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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