Drug interactions
Ketoconazole + Piroxicam
Severity: Minor
Ketoconazole and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may modestly raise piroxicam exposure, which could increase gastrointestinal and renal adverse effects. The clinical significance is generally small.
What this interaction means in plain words
Ketoconazole and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketoconazole belongs to Anti Fungals; Piroxicam belongs to Musculoskeletal.
Why it happens
Ketoconazole may inhibit CYP2C9-mediated metabolism of piroxicam.
What to do
No routine dose change is needed. Watch for gastrointestinal upset or bleeding signs during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Piroxicam?
MediHelp rates the interaction as minor. Ketoconazole and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole may modestly raise piroxicam exposure, which could increase gastrointestinal and renal adverse effects. The clinical significance is generally small.
How serious is the interaction between Ketoconazole and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for gastrointestinal upset or bleeding signs during prolonged co-therapy.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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