Drug interactions
Ketoconazole + Pomalidomide
Severity: Moderate
Ketoconazole and Pomalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may modestly increase pomalidomide exposure, although the effect is not large in studies with strong CYP3A4/P-gp inhibitors. Increased myelosuppression and neuropathy are theoretical concerns.
What this interaction means in plain words
Ketoconazole and Pomalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Pomalidomide belongs to Miscellaneous.
Why it happens
Possible inhibition of CYP1A2, CYP3A4 and P-glycoprotein involved in pomalidomide clearance.
What to do
Monitor blood counts regularly and watch for adverse effects; labeling allows use with strong CYP3A4/P-gp inhibitors without routine dose change, but avoid strong CYP1A2 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Ketoconazole with Pomalidomide?
MediHelp rates the interaction as moderate. Ketoconazole and Pomalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole may modestly increase pomalidomide exposure, although the effect is not large in studies with strong CYP3A4/P-gp inhibitors. Increased myelosuppression and neuropathy are theoretical concerns.
How serious is the interaction between Ketoconazole and Pomalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly and watch for adverse effects; labeling allows use with strong CYP3A4/P-gp inhibitors without routine dose change, but avoid strong CYP1A2 inhibitors.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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