Drug interactions
Ketoconazole + Pravastatin
Severity: Minor
Ketoconazole and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pravastatin is not significantly metabolized by CYP3A4, so ketoconazole has little expected effect on its levels. Any increase in exposure through transporter inhibition is likely small.
What this interaction means in plain words
Ketoconazole and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketoconazole belongs to Anti Fungals; Pravastatin belongs to Cardiovascular.
Why it happens
Possible inhibition of OATP1B1 hepatic uptake of pravastatin by ketoconazole; the effect is not well established.
What to do
No dose adjustment is usually required; counsel patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Pravastatin
Frequently asked questions
Can I take Ketoconazole with Pravastatin?
MediHelp rates the interaction as minor. Ketoconazole and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pravastatin is not significantly metabolized by CYP3A4, so ketoconazole has little expected effect on its levels. Any increase in exposure through transporter inhibition is likely small.
How serious is the interaction between Ketoconazole and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; counsel patients to report unexplained muscle pain or weakness.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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