Drug interactions
Ketoconazole + Ripretinib
Severity: Moderate
Ketoconazole and Ripretinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole increases exposure to ripretinib and its active metabolite. This may increase adverse reactions such as palmar-plantar erythrodysesthesia, hypertension and myalgia.
What this interaction means in plain words
Ketoconazole and Ripretinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Ripretinib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition by ketoconazole reduces ripretinib and metabolite clearance.
What to do
Monitor closely for ripretinib toxicity and manage adverse reactions per labeling, or choose an antifungal with less CYP3A4 inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Ripretinib
- Amobarbital + Ripretinib Major
- Apalutamide + Ripretinib Major
- Carbamazepine + Ripretinib Major
- Efavirenz + Ripretinib Major
- Enzalutamide + Ripretinib Major
- Phenytoin + Ripretinib Major
Frequently asked questions
Can I take Ketoconazole with Ripretinib?
MediHelp rates the interaction as moderate. Ketoconazole and Ripretinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole increases exposure to ripretinib and its active metabolite. This may increase adverse reactions such as palmar-plantar erythrodysesthesia, hypertension and myalgia.
How serious is the interaction between Ketoconazole and Ripretinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for ripretinib toxicity and manage adverse reactions per labeling, or choose an antifungal with less CYP3A4 inhibition.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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