Drug interactions
Ketoconazole + Rosuvastatin
Severity: Minor
Ketoconazole and Rosuvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may modestly raise rosuvastatin exposure, but rosuvastatin is little metabolized by CYP3A4, so the effect is small. The clinical relevance is limited and myopathy risk is only slightly increased.
What this interaction means in plain words
Ketoconazole and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketoconazole belongs to Anti Fungals; Rosuvastatin belongs to Cardiovascular.
Why it happens
Possible weak inhibition of hepatic uptake transporters such as OATP1B1 leading to small increases in rosuvastatin levels.
What to do
No dose change is usually needed. Advise patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Ketoconazole with Rosuvastatin?
MediHelp rates the interaction as minor. Ketoconazole and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole may modestly raise rosuvastatin exposure, but rosuvastatin is little metabolized by CYP3A4, so the effect is small. The clinical relevance is limited and myopathy risk is only slightly increased.
How serious is the interaction between Ketoconazole and Rosuvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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