Drug interactions
Ketoconazole + Tazemetostat
Severity: Major
Ketoconazole and Tazemetostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole raises tazemetostat exposure, which could increase adverse effects including the risk of secondary malignancies and other toxicities.
What this interaction means in plain words
Ketoconazole and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoconazole belongs to Anti Fungals; Tazemetostat belongs to Miscellaneous.
Why it happens
Strong inhibition of CYP3A4-mediated metabolism of tazemetostat.
What to do
Avoid strong CYP3A4 inhibitors; if unavoidable, reduce the tazemetostat dose per labeling and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Ketoconazole with Tazemetostat?
MediHelp rates the interaction as major. Ketoconazole and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole raises tazemetostat exposure, which could increase adverse effects including the risk of secondary malignancies and other toxicities.
How serious is the interaction between Ketoconazole and Tazemetostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inhibitors; if unavoidable, reduce the tazemetostat dose per labeling and monitor for toxicity.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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