Drug interactions
Ketoprofen + Milnacipran
Severity: Moderate
Ketoprofen and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin-norepinephrine reuptake inhibitors impair platelet aggregation, and combined with NSAIDs the risk of gastrointestinal and other bleeding rises substantially.
What this interaction means in plain words
Ketoprofen and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Milnacipran belongs to Central Nervous System.
Why it happens
Depletion of platelet serotonin by reuptake inhibition adds to NSAID inhibition of platelet cyclooxygenase and gastric mucosal injury.
What to do
Monitor for signs of bleeding and consider gastroprotection with a proton pump inhibitor in at-risk patients, or use paracetamol for analgesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Ketoprofen with Milnacipran?
MediHelp rates the interaction as moderate. Ketoprofen and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonin-norepinephrine reuptake inhibitors impair platelet aggregation, and combined with NSAIDs the risk of gastrointestinal and other bleeding rises substantially.
How serious is the interaction between Ketoprofen and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider gastroprotection with a proton pump inhibitor in at-risk patients, or use paracetamol for analgesia.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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