Drug interactions
Ketoprofen + Nadolol
Severity: Moderate
Ketoprofen and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood pressure lowering effect of beta-blockers, particularly with continued use over more than a week. Fluid retention and a rise in blood pressure may occur, and renal function can be affected.
What this interaction means in plain words
Ketoprofen and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Nadolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal and vascular prostaglandin synthesis causes sodium and water retention and vasoconstriction that oppose the antihypertensive effect.
What to do
Monitor blood pressure when an NSAID is started, continued or stopped, and adjust the antihypertensive dose if needed. Use the shortest NSAID course possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Ketoprofen with Nadolol?
MediHelp rates the interaction as moderate. Ketoprofen and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the blood pressure lowering effect of beta-blockers, particularly with continued use over more than a week. Fluid retention and a rise in blood pressure may occur, and renal function can be affected.
How serious is the interaction between Ketoprofen and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when an NSAID is started, continued or stopped, and adjust the antihypertensive dose if needed. Use the shortest NSAID course possible.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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