Drug interactions
Ketoprofen + Nebivolol
Severity: Moderate
Ketoprofen and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular NSAID use can reduce the antihypertensive effect of beta-blockers such as nebivolol. Blood pressure control may worsen, especially after more than a week of NSAID therapy.
What this interaction means in plain words
Ketoprofen and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Nebivolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins leads to sodium and fluid retention that counteracts the beta-blocker's effect.
What to do
Check blood pressure regularly during NSAID co-therapy and increase the antihypertensive dose if required. Prefer short NSAID courses or an alternative analgesic such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Ketoprofen with Nebivolol?
MediHelp rates the interaction as moderate. Ketoprofen and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular NSAID use can reduce the antihypertensive effect of beta-blockers such as nebivolol. Blood pressure control may worsen, especially after more than a week of NSAID therapy.
How serious is the interaction between Ketoprofen and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure regularly during NSAID co-therapy and increase the antihypertensive dose if required. Prefer short NSAID courses or an alternative analgesic such as paracetamol.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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