Drug interactions
Ketoprofen + Oxaprozin
Severity: Major
Ketoprofen and Oxaprozin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of two NSAIDs offers no additional analgesic advantage and raises the risk of gastrointestinal bleeding, kidney injury and cardiovascular events.
What this interaction means in plain words
Ketoprofen and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoprofen belongs to Musculoskeletal; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition with reduced platelet function and loss of gastric and renal prostaglandin protection.
What to do
Avoid combining the two and use one NSAID at the lowest effective dose. Consider gastroprotection in at-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Ketoprofen with Oxaprozin?
MediHelp rates the interaction as major. Ketoprofen and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use of two NSAIDs offers no additional analgesic advantage and raises the risk of gastrointestinal bleeding, kidney injury and cardiovascular events.
How serious is the interaction between Ketoprofen and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two and use one NSAID at the lowest effective dose. Consider gastroprotection in at-risk patients.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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