Drug interactions
Ketoprofen + Pemetrexed
Severity: Major
Ketoprofen and Pemetrexed: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen can raise pemetrexed exposure, particularly in patients with reduced renal function. This may increase myelosuppression, renal toxicity and gastrointestinal toxicity.
What this interaction means in plain words
Ketoprofen and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoprofen belongs to Musculoskeletal; Pemetrexed belongs to Oncology.
Why it happens
NSAIDs reduce renal function and may compete for tubular secretion, decreasing pemetrexed clearance.
What to do
In patients with mild to moderate renal impairment, avoid ketoprofen for 2 days before, the day of and 2 days after pemetrexed. Monitor blood counts and renal function if an NSAID cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Pemetrexed
Frequently asked questions
Can I take Ketoprofen with Pemetrexed?
MediHelp rates the interaction as major. Ketoprofen and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoprofen can raise pemetrexed exposure, particularly in patients with reduced renal function. This may increase myelosuppression, renal toxicity and gastrointestinal toxicity.
How serious is the interaction between Ketoprofen and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients with mild to moderate renal impairment, avoid ketoprofen for 2 days before, the day of and 2 days after pemetrexed. Monitor blood counts and renal function if an NSAID cannot be avoided.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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