Drug interactions
Ketoprofen + Phentolamine
Severity: Minor
Ketoprofen and Phentolamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce the blood pressure lowering effect of alpha-blockers like phentolamine. The effect is generally modest and variable.
What this interaction means in plain words
Ketoprofen and Phentolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketoprofen belongs to Musculoskeletal; Phentolamine belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and fluid retention opposes the vasodilating action.
What to do
Monitor blood pressure if the NSAID is used regularly and adjust the antihypertensive dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Ketoprofen with Phentolamine?
MediHelp rates the interaction as minor. Ketoprofen and Phentolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may reduce the blood pressure lowering effect of alpha-blockers like phentolamine. The effect is generally modest and variable.
How serious is the interaction between Ketoprofen and Phentolamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if the NSAID is used regularly and adjust the antihypertensive dose if control is lost.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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