Drug interactions
Ketoprofen + Pivmecillinam
Severity: Minor
Ketoprofen and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen can reduce the renal tubular secretion of penicillin-type antibiotics such as mecillinam, which may raise antibiotic levels. The clinical relevance is usually small given the wide therapeutic index of beta-lactams.
What this interaction means in plain words
Ketoprofen and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketoprofen belongs to Musculoskeletal; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Competition for renal tubular organic anion transport and plasma protein binding may modestly reduce mecillinam clearance.
What to do
No routine adjustment is needed. Consider monitoring renal function in patients with impaired kidney function or on high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Ketoprofen with Pivmecillinam?
MediHelp rates the interaction as minor. Ketoprofen and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoprofen can reduce the renal tubular secretion of penicillin-type antibiotics such as mecillinam, which may raise antibiotic levels. The clinical relevance is usually small given the wide therapeutic index of beta-lactams.
How serious is the interaction between Ketoprofen and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Consider monitoring renal function in patients with impaired kidney function or on high doses.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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