Drug interactions
Ketoprofen + Pralatrexate
Severity: Moderate
Ketoprofen and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce pralatrexate elimination and raise its exposure, increasing the risk of mucositis, myelosuppression and other toxicities. The risk is greater with impaired renal function.
What this interaction means in plain words
Ketoprofen and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
Why it happens
Reduced renal clearance through competition for tubular secretion and NSAID-related lowering of renal blood flow.
What to do
Monitor for mucositis and blood count changes and check renal function; adjust the pralatrexate dose if toxicity develops. Avoid NSAIDs in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Pralatrexate
Frequently asked questions
Can I take Ketoprofen with Pralatrexate?
MediHelp rates the interaction as moderate. Ketoprofen and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce pralatrexate elimination and raise its exposure, increasing the risk of mucositis, myelosuppression and other toxicities. The risk is greater with impaired renal function.
How serious is the interaction between Ketoprofen and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mucositis and blood count changes and check renal function; adjust the pralatrexate dose if toxicity develops. Avoid NSAIDs in patients with renal impairment.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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