Drug interactions
Ketoprofen + Prasugrel
Severity: Major
Ketoprofen and Prasugrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prasugrel is a potent antiplatelet drug and ketoprofen impairs platelet function and damages the gastric mucosa. Together they increase the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Ketoprofen and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoprofen belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Additive impairment of platelet function (P2Y12 blockade plus reversible COX-1 inhibition) with NSAID-related mucosal injury.
What to do
Avoid regular NSAID use with prasugrel where possible and use acetaminophen for analgesia. If an NSAID is essential, use the shortest course and consider gastroprotection with a proton pump inhibitor, monitoring for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Ketoprofen with Prasugrel?
MediHelp rates the interaction as major. Ketoprofen and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prasugrel is a potent antiplatelet drug and ketoprofen impairs platelet function and damages the gastric mucosa. Together they increase the risk of gastrointestinal and other bleeding.
How serious is the interaction between Ketoprofen and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with prasugrel where possible and use acetaminophen for analgesia. If an NSAID is essential, use the shortest course and consider gastroprotection with a proton pump inhibitor, monitoring for bleeding.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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