Drug interactions
Ketoprofen + Probenecid
Severity: Moderate
Ketoprofen and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen can raise probenecid levels, and probenecid markedly raises ketoprofen concentrations by reducing its elimination. Ketoprofen exposure may increase enough to cause more NSAID adverse effects.
What this interaction means in plain words
Ketoprofen and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Competition for renal tubular organic anion secretion and probenecid inhibition of ketoprofen glucuronide conjugation reduce clearance.
What to do
Consider a lower ketoprofen dose and monitor for GI, renal and other NSAID adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Ketoprofen with Probenecid?
MediHelp rates the interaction as moderate. Ketoprofen and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoprofen can raise probenecid levels, and probenecid markedly raises ketoprofen concentrations by reducing its elimination. Ketoprofen exposure may increase enough to cause more NSAID adverse effects.
How serious is the interaction between Ketoprofen and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower ketoprofen dose and monitor for GI, renal and other NSAID adverse effects.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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