Drug interactions
Ketoprofen + Sertraline
Severity: Moderate
Ketoprofen and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Co-administration of an SSRI and an NSAID increases the risk of upper gastrointestinal bleeding compared with either alone. Older patients and those with prior GI bleeding are most vulnerable.
What this interaction means in plain words
Ketoprofen and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Sertraline belongs to Central Nervous System.
Why it happens
SSRI-induced platelet serotonin depletion combined with NSAID platelet inhibition and mucosal injury.
What to do
Avoid prolonged combined use when possible; otherwise add a proton pump inhibitor and counsel on bleeding symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Ketoprofen with Sertraline?
MediHelp rates the interaction as moderate. Ketoprofen and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Co-administration of an SSRI and an NSAID increases the risk of upper gastrointestinal bleeding compared with either alone. Older patients and those with prior GI bleeding are most vulnerable.
How serious is the interaction between Ketoprofen and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged combined use when possible; otherwise add a proton pump inhibitor and counsel on bleeding symptoms.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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