Drug interactions
Ketoprofen + Sparsentan
Severity: Major
Ketoprofen and Sparsentan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is a dual endothelin and angiotensin II receptor antagonist that lowers glomerular pressure, and NSAIDs can further reduce renal perfusion. The combination may worsen kidney function and raise potassium.
What this interaction means in plain words
Ketoprofen and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoprofen belongs to Musculoskeletal; Sparsentan belongs to Genitourinary.
Why it happens
NSAID afferent arteriolar vasoconstriction combined with angiotensin receptor and endothelin blockade reduces glomerular filtration and potassium excretion.
What to do
Avoid regular NSAID use and use acetaminophen for pain where possible. If an NSAID is needed, monitor serum creatinine and potassium and watch for volume depletion.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Ketoprofen with Sparsentan?
MediHelp rates the interaction as major. Ketoprofen and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sparsentan is a dual endothelin and angiotensin II receptor antagonist that lowers glomerular pressure, and NSAIDs can further reduce renal perfusion. The combination may worsen kidney function and raise potassium.
How serious is the interaction between Ketoprofen and Sparsentan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use and use acetaminophen for pain where possible. If an NSAID is needed, monitor serum creatinine and potassium and watch for volume depletion.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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