Drug interactions
Ketoprofen + Vancomycin
Severity: Moderate
Ketoprofen and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce glomerular filtration and slow vancomycin elimination, an effect reported mainly in neonates given indomethacin or ibuprofen. Both drugs can harm the kidney, so combined use may increase nephrotoxicity and vancomycin exposure.
What this interaction means in plain words
Ketoprofen and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Vancomycin belongs to Anti Bacterial.
Why it happens
NSAID-induced renal hypoperfusion lowers vancomycin clearance, with additive nephrotoxic effects.
What to do
Monitor vancomycin trough or AUC-guided levels and serum creatinine. Avoid or minimize the NSAID in patients with renal risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ketoprofen and Vancomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Ketoprofen with Vancomycin?
MediHelp rates the interaction as moderate. Ketoprofen and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce glomerular filtration and slow vancomycin elimination, an effect reported mainly in neonates given indomethacin or ibuprofen. Both drugs can harm the kidney, so combined use may increase nephrotoxicity and vancomycin exposure.
How serious is the interaction between Ketoprofen and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor vancomycin trough or AUC-guided levels and serum creatinine. Avoid or minimize the NSAID in patients with renal risk factors.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
